Tag Archives: chronic wounds

Breaking silos: Effective wound healing means treatment across the continuum

Around 6.5 million patients in the U.S. suffer from chronic wounds, such as pressure injuries or ulcers. Treatment costs $25 billion each year, representing a sizable and growing problem. Despite the wide impact of chronic wounds, it’s rare to see specialized, effective wound care delivered across the care continuum.

A chronic non-healing wound is a surrogate marker for illness. These patients require holistic management of their co-morbidities and continuity across care settings.

Despite this, a great deal of emphasis has been placed on treating wounds as singular events, managed topically with expensive dressings and support surfaces. This is only a small part of wound healing.

As a physician focused solely on wound care, I have learned that we must shift the focus from simply treating the wound to treating the wounded patient. The impact in the post-acute care setting in particular is worthy of evaluation and discussion, as up to 29% of patients in long-term care facilities will experience a pressure ulcer, posing serious legal, financial, and staffing implications.

For those providers working outside long-term care, there is little understanding of challenges facing LTC providers. Acute providers do not often ask, for example, how are my LTC partners reimbursed? How are they staffed? What are the requirements and regulatory pressures they face? Asking these questions would facilitate a more productive dialogue with a focus on collaborative prevention, rather than waiting until a chronic wound occurs in the LTC setting.

Creating an integrated wound care community

To address the needs of the present and growing population of patients with chronic wounds, Healogics developed an integrated wound care community model, to coordinate the wound healing process across all care settings. The program utilizes Healogics Specialty Physicians, a subspecialty group of physicians and providers with extensive training solely focused on wound care.

HSPs provide expert inpatient consultation and ensure safe transition of patients out of the hospital into the appropriate care setting. Because HSPs see the patient regardless of post-discharge venue, patients receive the same quality of care whether they are going home, to a skilled-nursing, assisted living, or LTC setting. Because chronic wounds are surrogate markers for illness, we have realized it’s essential to have an integrated, multi-setting, and multi-disciplinary process to treat the patient and their co-morbidities.

Data collected at a pilot IWCC site in the Midwestern U.S. from 2014 to 2016 revealed very positive trends for chronic wound patients. In the acute care setting, the average length of stay decreased from 9.41 days to 5.64 days, and total cost of care per patient was reduced from $10,670 to $7,248.

We’re excited by these promising results, which were revealed at the American College of Wound Healing and Tissue Repair Conference last December. We look forward to refining and expanding the model by helping our partners in acute and LTC settings standardize their practices, use evidence-based clinical guidelines, mobilize technologies and processes, and pay critical attention to patient safety and value-based outcomes.

When it comes to wound healing, no venue of care should operate alone—an integrated solution that creates continuity for the patient is critical. There are four things LTC facilities can do to break down the silos:

Read more at McKnight’s

Wound Photography – How it Benefits Clinical Documentation

Accurate assessment and documentation of wounds is essential for developing a comprehensive plan of care. Photography now plays a key role in wound care. The use of digital photography has enhanced the reliability and accuracy of wound documentation. Though a wound assessment in patient files includes details such as location, depth, odor, condition of surrounding tissue and other details, a visual record can be worth even more.

Digital photography is becoming a more prevalent documentation tool. According to an article published in McKnight’s, forensic nursing experts recommend using photographs to document injury. The photos show both how an injury occurred and how it is healing.

The National Pressure Ulcer Advisory Panel (NPUAP) also supports photography as a more accurate means for assessment of wound dimensions and wound base over time.

A visual confirmation to the written record, these images:

  • Facilitate better diagnosis
  • Enhance clinical documentation
  • Help to monitor the progress of wound healing
  • Help prevent litigation in wound management
  • Allow inter-disciplinary communication among the wound care team

Read more at Wound Wizard

Opioid Treatment and Chronic Wound Healing

While opioids are routinely prescribed for painful and chronic wounds, the effects of the medications are not well described in literature. Past studies suggest that stimulation of mu-opiate receptors on keratinocytes may induce transforming growth factor-beta (TGF-beta) and cytokeratin 16 (CK16), which are molecules that appear in wound healing environments. However, other studies suggest opioids may impede immune activation and negatively affect healing. This longitudinal observational study sought to elucidate the effect of opioids on healing of wounds in the Wound Healing and Etiology (WE-HEAL) Study, a repository of 450 patients. Parameters such as pain score, longitudinal opioid exposure, and total wound surface area (tWSA) were investigated. Continue reading »

Preparing the wound bed: Basic strategies, novel methods

The goal of wound-bed preparation is to create a stable, well-vascularized environment that aids healing of chronic wounds. Without proper preparation, even the most expensive wound-care products and devices are unlikely to produce positive outcomes.

To best prepare the wound bed, you need to understand wound healing physiology and wound care basics, as well as how to evaluate the patient’s overall health and manage wounds that don’t respond to treatment. (See Normal wound healing.)

Basic wound care: DIME

To choose the right method of wound-bed preparation for a particular wound, first assess your patient’s condition, wound history, physical wound characteristics, and availability of resources. Local wound-bed preparation factors can be summarized by the acronym DIME—Debridement, Infection or Inflammation, Moisture balance, and Epithelial advancement. These four components address the various pathophysiologic abnormalities underlying chronic wounds.

D: Debridement

Nonviable tissue must be debrided because cell debris impairs healing. Research and clinical evidence show that debriding necrotic or fibrous tissue accelerates wound healing. (See Types of debridement.)

I: Infection or inflammation

Bacterial load directly impacts wound-bed preparation. Assess and treat the patient’s wound for superficial or serious infection, persistent inflammation, extensive colonization, and cellulitis. With infection or inflammation, wound healing stalls because the extracellular matrix and growth factors degrade more rapidly than they synthesize, impeding progression toward the proliferative phase and ultimately affecting re-epithelialization. Managing the bacterial load with local or systemic therapy is crucial to wound-bed preparation.

M: Moisture balance

Appropriate moisture promotes the action of growth factors and cytokines and aids migration of cells, including fibroblasts and keratinocytes. However, attaining a moisture balance is challenging. Excessive moisture can damage the wound bed and surrounding skin, leading to maceration and skin breakdown. Inadequate moisture, on the other hand, can impede cellular activities and promote eschar, resulting in poor wound healing.

Be sure to evaluate the patient’s nutritional status, cardiac and peripheral vascular status, and renal function. Check for risk factors that can cause moisture imbalance. Then identify an appropriate treatment plan. To increase compliance, explain planned interventions to patients and their caregivers. The typical plan includes medical wound management strategies, such as manual lymph drainage, compression devices and garments, absorptive dressings, and negative pressure wound therapy.

E: Epithelial advancement

Cellular dysfunction and biochemical imbalance can stall wound-bed progression by impeding epidermal cell and keratinocyte migration. Migration of epidermal cells and keratinocytes indicates the wound bed is adequately prepared. Wound contraction is another key sign of an adequately prepared wound bed.

Assessing the patient’s overall health

Remember—you must treat the patient before you can treat the wound. Especially with difficult wounds, multiple comorbidities can delay or interrupt re-epithelialization. Adequate nutrition and smoking cessation are especially important. (See How smoking and poor nutrition impair wound healing.)

Checking for wound-specific problems

Assess the patient for two wound-specific problems—biofilms and abnormal matrix.

Biofilms delay wound healing by creating a host-pathogen environment that promotes cohabitation of many bacterial species and anaerobes. These bacteria promote their own survival within the wound environment. Elderly patients and those with complex diseases, diabetic foot ulcers, venous leg ulcers, or pressure ulcers may develop extensive bacterial populations. That’s why restoring bacterial balance is important in managing chronic wounds. Techniques for managing biofilms effectively include use of topical agents or systemic antibiotics and regular maintenance debridement.

Abnormal matrix can develop in chronic wounds containing proteases that digest fibronectin and growth factors in the fibrin clot, causing a degraded matrix that no longer supports re-epithelialization or formation of granulation tissue.

Managing wounds unresponsive to treatment

Cells in chronic wounds become unresponsive, unable to divide or respond to such messengers as cytokines and growth factors. This results in phenotypic dysregulation. For successful wound-bed preparation, options may include bioengineered skin-cell therapy, stem-cell therapies, and platelet-rich plasma (PRP) for cutaneous wounds.

Bioengineered skin-cell therapy

Bioengineering treatments have provided viable therapeutic options, especially in managing chronic or difficult-to-heal wounds. Bioengineered skin and soft-tissue substitutes can be acellular or cellular.

Acellular products contain a matrix or scaffold composed of such materials as collagen, hyaluronic acid, and fibronectin. These products differ in various ways, including:

species source (human, bovine, or porcine)

tissue source (such as dermis, pericardium, or intestinal mucosa)

additives (for instance, antibiotics or surfactants)

hydration (wet or freeze-dried)

required preparation (multiple rinses or rehydration).

Cellular products contain living cells, such as fibroblasts and keratinocytes within the matrix. Cells within the matrix may be autologous, allogeneic, or derived from other species (such as sheep or pigs). Skin substitutes also may be composed of dermal cells, epidermal cells, or a combination and may provide growth factors to stimulate healing. Topical growth factors are used as an adjuvant treatment to such therapies as debridement, off-loading, frequent dressing changes, and compression of wounds caused by vascular insufficiency

Stem-cell therapy

Use of stem cells in tissue regeneration has significant potential in cutaneous wound-bed preparation. Stem cells act in several ways to aid wound repair; in chronic wounds, they  could serve as an additional tool for therapeutic augmentation. This combined mode of repair and regeneration probably explains why cell therapies are more effective than simpler alternatives, such as direct growth-factor therapy treatment.


Multiple studies since the 1990s have shown promising results for PRP. For instance, researchers found PRP gel accelerates bone regeneration and studies confirmed the presence of specific platelet-derived growth factor receptors (PDGFs) in bone tissue. Research has uncovered strong evidence that these therapies are effective.

The PRP gel aids molecular and cellular induction of normal wound-healing responses, similar to platelet activation. In addition, PRP contains several growth factors and other cytokines that stimulate healing of bone and soft tissues. Autologous PRP is an advanced wound therapy used for hard-to-heal acute and chronic wounds.

Growth factors such as topical PDGF can help correct matrix abnormalities of growth factors. Also, studies have found that accelerated wound healing follows topical application of epidermal growth factor derived from the patient’s own cultured keratino cytes, delivered in a fluid compress.

A systematic approach

When preparing the patient’s wound bed and managing the wound, use a systematic approach that helps remove barriers to healing. Proper preparation helps ensure optimal patient outcomes.

Kulbir Dhillon is a nurse practitioner and wound care specialist with VA HBPC in Sacramento, California.

Selected references

Falanga V. Wound bed preparation: science applied to practice. In: Wound Bed Preparation in PracticeEWMA Position Document. London: Medical Education Partnership Ltd;2004;2-5.

Fitzgerald RH, Armstrong DG. Palliative advanced wound care. Vein Mag. 2009;2(2):44-6.

Harris RJ. The nursing practice of conservative sharp wound debridement: promotion, education and proficiency. Wound Care Canada. 2009;7(1):22-30.

Hess CT. Checklist for factors affecting wound healing. Adv Skin Wound Care. 2011;24(4):192.

Knox KR, Datiashvili RO, Granick MS. Surgical wound bed preparation of chronic and acute wounds. Clin Plast Surg. 2007;34(4):633-41.

Laplaud AL, Blaizot X, Gaillard C, et al. Wound debridement: comparative reliability of three methods for measuring fibrin percentage in chronic wounds. Wound Repair Regen. 2010;18(1):13-20.

Ligresti C, Bo F. Wound bed preparation of difficult wounds: an evolution of the principles of TIME. Int Wound J. 2007;4(1):21-9.

Mustoe TA, O’Shaughnessy K, Kloeters O. Chronic wound pathogenesis and current treatment strategies: a unifying hypothesis. Plast Reconstr Surg. 2006;117(7 Suppl):35S-41S.

Opletalová K, Blaizot X, Mourgeon B, et al. Maggot therapy for wound debridement: a randomized multicenter trial. Arch Dermatol. 2012;148(4):432-8.

Panuncialman J, Falanga V. The science of wound bed preparation. Surg Clin North Am. 2009;89(3):611-26.

Paul AG, Ahmad NW, Lee HL, et al. Maggot debridement therapy with Lucilia cuprina: a comparison with conventional debridement in diabetic foot ulcers. Int Wound J. 2009;6(1):39-46.

Payne WG, Salas RE, Ko F, et al. Enzymatic debriding agents are safe in wounds with high bacterial bioburdens and stimulate healing. Eplasty. 2008;7;8:e17.

Sardina D. Wound bed preparation. In: Skin and Wound Management Course Workbook. Lake Geneva, WI: Wound Care Education Institute; August 2010;5:42-58.

Sibbald RG, Goodman L, Woo KY, et al. Special considerations in wound bed preparation 2011: an update. Adv Skin Wound Care. 2011;24(9):415-36.

Sibbald RG, Orsted HL, Schultz GS, et al. Preparing the wound bed 2003: focus on infection and inflammation. Ostomy Wound Manage. 2003;49(11):23-51.

Wolcott RD, Rumbaugh KP, James G. Biofilm maturity studies indicate sharp debridement opens a time-dependent therapeutic window. J Wound Care. 2010;19(8):320-8.